Cadherin 11 Inhibition Downregulates β-catenin, Deactivates the Canonical WNT Signalling Pathway and Suppresses the Cancer Stem Cell-Like Phenotype of Triple Negative Breast Cancer

Cadherin 11 Inhibition Downregulates β-catenin, Deactivates the Canonical WNT Signalling Pathway and Suppresses the Cancer Stem Cell-Like Phenotype of Triple Negative Breast Cancer

Background: Cancer stem cells (CSCs) promote tumor progression and distant metastasis in breast cancer. Cadherin 11 (CDH11) is overexpressed in invasive breast cancer cells and implicated in distant bone metastases in several cancers. The WNT signalling pathway regulates CSC activity. Growing eviden...

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Bibliographic Details
Main Authors: Pamungkas Bagus Satriyo, Oluwaseun Adebayo Bamodu, Jia-Hong Chen, Teguh Aryandono, Sofia Mubarika Haryana, Chi-Tai Yeh, Tsu-Yi Chao
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Journal of Clinical Medicine
Subjects:
Cadherin 11
WNT signaling
β-catenin
cancer stem cells
TNBC
Online Access:https://www.mdpi.com/2077-0383/8/2/148

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https://www.mdpi.com/2077-0383/8/2/148

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