Inhibition of TMEM16A by Natural Product Silibinin: Potential Lead Compounds for Treatment of Lung Adenocarcinoma

Inhibition of TMEM16A by Natural Product Silibinin: Potential Lead Compounds for Treatment of Lung Adenocarcinoma

Background: Effective anticancer therapy can be achieved by identifying novel tumor-specific drug targets and screening of new drugs. Recently, TMEM16A has been identified to be overexpressed in lung adenocarcinoma, and inhibitors of TMEM16A showed obvious antitumor efficacy.Methods: YFP fluorescenc...

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Bibliographic Details
Main Authors: Shuai Guo, Xue Bai, Yufei Liu, Sai Shi, Xuzhao Wang, Yong Zhan, Xianjiang Kang, Yafei Chen, Hailong An
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Pharmacology
Subjects:
TMEM16A
inhibitor
silibinin
lung adenocarcinoma
molecular target
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.643489/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.643489/full

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