Reduced binding of Pittsburgh Compound-B in areas of white matter hyperintensities

The amyloid imaging agent, Pittsburgh Compound-B, binds with high affinity to β-amyloid (Aβ) in the brain, and it is well established that PiB also shows non-specific retention in white matter (WM). However, little is known about retention of PiB in areas of white matter hyperintensities (WMH), abno...

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Bibliographic Details
Main Authors: A.E. Goodheart, E. Tamburo, D. Minhas, H.J. Aizenstein, E. McDade, B.E. Snitz, J.C. Price, C.A. Mathis, O.L. Lopez, W.E. Klunk, A.D. Cohen
Format: Article
Language:English
Published: Elsevier 2015-01-01
Series:NeuroImage: Clinical
Subjects:
PiB
PET
Online Access:http://www.sciencedirect.com/science/article/pii/S2213158215001692