CAF secreted miR-522 suppresses ferroptosis and promotes acquired chemo-resistance in gastric cancer

CAF secreted miR-522 suppresses ferroptosis and promotes acquired chemo-resistance in gastric cancer

Abstract Background Ferroptosis is a novel mode of non-apoptotic cell death induced by build-up of toxic lipid peroxides (lipid-ROS) in an iron dependent manner. Cancer-associated fibroblasts (CAFs) support tumor progression and drug resistance by secreting various bioactive substances, including ex...

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Bibliographic Details
Main Authors: Haiyang Zhang, Ting Deng, Rui Liu, Tao Ning, Haiou Yang, Dongying Liu, Qiumo Zhang, Dan Lin, Shaohua Ge, Ming Bai, Xinyi Wang, Le Zhang, Hongli Li, Yuchong Yang, Zhi Ji, Hailong Wang, Guoguang Ying, Yi Ba
Format: Article
Language:English
Published: BMC 2020-02-01
Series:Molecular Cancer
Subjects:
Ferroptosis
Cancer-associated fibroblasts
Exosomes
miR-522
GC
Online Access:http://link.springer.com/article/10.1186/s12943-020-01168-8

Internet

http://link.springer.com/article/10.1186/s12943-020-01168-8

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