BGP: identifying gene-specific branching dynamics from single-cell data with a branching Gaussian process

BGP: identifying gene-specific branching dynamics from single-cell data with a branching Gaussian process

Abstract High-throughput single-cell gene expression experiments can be used to uncover branching dynamics in cell populations undergoing differentiation through pseudotime methods. We develop the branching Gaussian process (BGP), a non-parametric model that is able to identify branching dynamics fo...

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Bibliographic Details
Main Authors: Alexis Boukouvalas, James Hensman, Magnus Rattray
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Genome Biology
Subjects:
Single cell RNA-seq
Gaussian process
Branching dynamics
Online Access:http://link.springer.com/article/10.1186/s13059-018-1440-2

Internet

http://link.springer.com/article/10.1186/s13059-018-1440-2

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