Resistance of renal cell carcinoma to sorafenib is mediated by potentially reversible gene expression.

Resistance of renal cell carcinoma to sorafenib is mediated by potentially reversible gene expression.

Resistance to antiangiogenic therapy is an important clinical problem. We examined whether resistance occurs at least in part via reversible, physiologic changes in the tumor, or results solely from stable genetic changes in resistant tumor cells.Mice bearing two human RCC xenografts were treated wi...

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Bibliographic Details
Main Authors: Liang Zhang, Manoj Bhasin, Rachel Schor-Bardach, Xiaoen Wang, Michael P Collins, David Panka, Prabhakar Putheti, Sabina Signoretti, David C Alsop, Towia Libermann, Michael B Atkins, James W Mier, S Nahum Goldberg, Rupal S Bhatt
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-04-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3084751?pdf=render

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http://europepmc.org/articles/PMC3084751?pdf=render

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