Mutations I117V and I117M and Oseltamivir Sensitivity of Pandemic (H1N1) 2009 Viruses

Analysis of mutations I117V and I117M in the neuraminidase of influenza A pandemic (H1N1) 2009 viruses showed that I117V confers a mild reduction in oseltamivir sensitivity and has a synergistic effect of further increasing resistance when combined with H275Y. Contrary to recent reports, the I117M m...

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Bibliographic Details
Main Authors: Aeron C. Hurt, Sook Kwan Leang, David J. Speers, Ian Barr, Sebastian Maurer-Stroh
Format: Article
Language:English
Published: Centers for Disease Control and Prevention 2012-01-01
Series:Emerging Infectious Diseases
Subjects:
Online Access:https://wwwnc.cdc.gov/eid/article/18/1/11-1079_article