Deficiency of CCAAT/enhancer binding protein family DNA binding prevents malignant conversion of adenoma to carcinoma in NNK-induced lung carcinogenesis in the mouse

Deficiency of CCAAT/enhancer binding protein family DNA binding prevents malignant conversion of adenoma to carcinoma in NNK-induced lung carcinogenesis in the mouse

<p>Abstract</p> <p>Background</p> <p>The CCAAT/enhancer binding proteins (C/EBPs) play important roles in carcinogenesis of many tumors including the lung. Since multiple C/EBPs are expressed in lung, the combinatorial expression of these C/EBPs on lung carcinogenesis i...

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Bibliographic Details
Main Authors: Kimura Shioko, Paiz Jorge, Yoneda Mitsuhiro, Kido Taketomo, Vinson Charles, Ward Jerrold M
Format: Article
Language:English
Published: BMC 2012-12-01
Series:Molecular Cancer
Subjects:
C/EBPs
Lung chemical carcinogenesis bioassay
Dominant negative
A-C/EBP
Transgenic mouse
4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone
NNK
Online Access:http://www.molecular-cancer.com/content/11/1/90

Internet

http://www.molecular-cancer.com/content/11/1/90

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