Human Cytomegalovirus miR-US5-2 Downregulation of GAB1 Regulates Cellular Proliferation and UL138 Expression through Modulation of Epidermal Growth Factor Receptor Signaling Pathways

Human Cytomegalovirus miR-US5-2 Downregulation of GAB1 Regulates Cellular Proliferation and UL138 Expression through Modulation of Epidermal Growth Factor Receptor Signaling Pathways

Human cytomegalovirus (HCMV) causes significant disease in immunocompromised individuals, including transplant patients. HCMV establishes latency in hematopoietic stem cells in the bone marrow. The mechanisms governing latency and reactivation of viral replication are complex and not fully understoo...

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Bibliographic Details
Main Authors: Meaghan H. Hancock, Jennifer Mitchell, Felicia D. Goodrum, Jay A. Nelson
Format: Article
Language:English
Published: American Society for Microbiology 2020-08-01
Series:mSphere
Subjects:
gab1
ul138
cytomegalovirus
mirna
Online Access:https://doi.org/10.1128/mSphere.00582-20

Internet

https://doi.org/10.1128/mSphere.00582-20

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