Treatment with senicapoc in a porcine model of acute respiratory distress syndrome

Abstract Background Senicapoc is a potent and selective blocker of KCa3.1, a calcium-activated potassium channel of intermediate conductance. In the present study, we investigated whether there is a beneficial effect of senicapoc in a large animal model of acute respiratory distress syndrome (ARDS)....

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Bibliographic Details
Main Authors: Asbjørn G. Petersen, Peter C. Lind, Anne-Sophie B. Jensen, Mark A. Eggertsen, Asger Granfeldt, Ulf Simonsen
Format: Article
Language:English
Published: SpringerOpen 2021-04-01
Series:Intensive Care Medicine Experimental
Subjects:
Pig
Online Access:https://doi.org/10.1186/s40635-021-00381-z