Apolipoprotein E deficiency induces a progressive increase in tissue iron contents with age in mice

Apolipoprotein E deficiency induces a progressive increase in tissue iron contents with age in mice

Association of both iron/hepcidin and apolipoprotein E (ApoE) with development of Alzheimer disease (AD) and atherosclerosis led us to hypothesize that ApoE might be required for body iron homeostasis. Here, we demonstrated that ApoE knock-out (KO) induced a progressive accumulation of iron with age...

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Bibliographic Details
Main Authors: Juan Ma, Christopher Qian, Yong Bao, Meng-Yue Liu, Hui-Min Ma, Meng-Qi Shen, Wei Li, Jiao-Jiao Wang, Yu-Xin Bao, Yong Liu, Ya Ke, Zhong-Ming Qian
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:Redox Biology
Subjects:
Apolipoprotein E knock-out (ApoE−/-) mice
Iron in liver and spleen
Transferrin receptor 1 (TfR1)
Ferroportin 1 (Fpn1)
Hepcidin
Nuclear factor erythroid 2-related factor-2 (Nrf2)
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231721000136

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http://www.sciencedirect.com/science/article/pii/S2213231721000136

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