Relaxin Can Mediate Its Anti-Fibrotic Effects by Targeting the Myofibroblast NLRP3 Inflammasome at the Level of Caspase-1

Relaxin Can Mediate Its Anti-Fibrotic Effects by Targeting the Myofibroblast NLRP3 Inflammasome at the Level of Caspase-1

IntroductionThe NLRP3 inflammasome produces interleukin (IL)-1β and IL-18, which when chronically activated by transforming growth factor (TGF)-β1, contribute to fibrosis. The recombinant form of the anti-fibrotic hormone, relaxin (RLX), suppresses the pro-fibrotic influence of TGF-β1 and toll-like...

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Bibliographic Details
Main Authors: Anita A. Pinar, Alexander Yuferov, Tracey A. Gaspari, Chrishan S. Samuel
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Pharmacology
Subjects:
fibrosis
myofibroblasts
NLRP3 inflammasome
caspase-1
relaxin
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.01201/full

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https://www.frontiersin.org/article/10.3389/fphar.2020.01201/full

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