In vivo nose-to-brain delivery of the hydrophilic antiviral ribavirin by microparticle agglomerates

In vivo nose-to-brain delivery of the hydrophilic antiviral ribavirin by microparticle agglomerates

Nasal administration has been proposed as a potential approach for the delivery of drugs to the central nervous system. Ribavirin (RBV), an antiviral drug potentially useful to treat viral infections both in humans and animals, has been previously demonstrated to attain several brain compartments af...

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Bibliographic Details
Main Authors: Alessandro Giuliani, Anna Giulia Balducci, Elisa Zironi, Gaia Colombo, Fabrizio Bortolotti, Luca Lorenzini, Viola Galligioni, Giampiero Pagliuca, Alessandra Scagliarini, Laura Calzà, Fabio Sonvico
Format: Article
Language:English
Published: Taylor & Francis Group 2018-01-01
Series:Drug Delivery
Subjects:
ribavirin
microparticles
agglomerates
nasal administration
brain delivery
Online Access:http://dx.doi.org/10.1080/10717544.2018.1428242

Internet

http://dx.doi.org/10.1080/10717544.2018.1428242

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