Cooperative unfolding of distinctive mechanoreceptor domains transduces force into signals

Cooperative unfolding of distinctive mechanoreceptor domains transduces force into signals

How cells sense their mechanical environment and transduce forces into biochemical signals is a crucial yet unresolved question in mechanobiology. Platelets use receptor glycoprotein Ib (GPIb), specifically its α subunit (GPIbα), to signal as they tether and translocate on von Willebrand factor (VWF...

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Bibliographic Details
Main Authors: Lining Ju, Yunfeng Chen, Lingzhou Xue, Xiaoping Du, Cheng Zhu
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-07-01
Series:eLife
Subjects:
mechanosensing
single molecule
leucine rich repeat
GPIb
platelet
calcium signaling
Online Access:https://elifesciences.org/articles/15447

Internet

https://elifesciences.org/articles/15447

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