Site-Specific Glycan-Masking/Unmasking Hemagglutinin Antigen Design to Elicit Broadly Neutralizing and Stem-Binding Antibodies Against Highly Pathogenic Avian Influenza H5N1 Virus Infections

Site-Specific Glycan-Masking/Unmasking Hemagglutinin Antigen Design to Elicit Broadly Neutralizing and Stem-Binding Antibodies Against Highly Pathogenic Avian Influenza H5N1 Virus Infections

The highly pathogenic avian influenza (HPAI) H5N1 viruses with the capability of transmission from birds to humans have a serious impact on public health. To date, HPAI H5N1 viruses have evolved into ten antigenically distinct clades that could cause a mismatch of vaccine strains and reduce vaccine...

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Bibliographic Details
Main Authors: Ting-Hsuan Chen, Ya-Lin Yang, Jia-Tsrong Jan, Chung-Chu Chen, Suh-Chin Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-07-01
Series:Frontiers in Immunology
Subjects:
hemagglutinin
glycan masking
glycan unmasking
H5N1
vaccine
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.692700/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.692700/full

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