Role of aberrant metalloproteinase activity in the pro-inflammatory phenotype of bronchial epithelium in COPD

Role of aberrant metalloproteinase activity in the pro-inflammatory phenotype of bronchial epithelium in COPD

<p>Abstract</p> <p>Background</p> <p>Cigarette smoke, the major risk factor for COPD, is known to activate matrix metalloproteinases in airway epithelium. We investigated whether metalloproteinases, particularly A Disintegrin and Metalloproteinase (ADAM)17, contribute t...

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Bibliographic Details
Main Authors: Postma Dirkje S, Slebos Dirk-Jan, Noordhoek Jacobien A, Brandenburg Simone M, Heijink Irene H, van Oosterhout Antoon J
Format: Article
Language:English
Published: BMC 2011-08-01
Series:Respiratory Research
Subjects:
Cigarette smoke
ADAM17
IL-8
TGF-α
TIMP-2
Online Access:http://respiratory-research.com/content/12/1/110

Internet

http://respiratory-research.com/content/12/1/110

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