GABA and valproate modulate trigeminovascular nociceptive transmission in the thalamus

Objective: To study the role of GABA receptors in thalamic relay neurons in the ventroposteromedial (VPM) nucleus of the rat activated by a trigeminovascular nociceptive stimulus in relationship to migraine, and the potential modulation of nociceptive transmission by GABA acting anti-convulsants.Met...

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Bibliographic Details
Main Authors: Anna P. Andreou, Kevin G. Shields, Peter J. Goadsby
Format: Article
Language:English
Published: Elsevier 2010-02-01
Series:Neurobiology of Disease
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996109002848