Vaccine-induced ICOS+CD38+ circulating Tfh are sensitive biosensors of age-related changes in inflammatory pathways

Vaccine-induced ICOS+CD38+ circulating Tfh are sensitive biosensors of age-related changes in inflammatory pathways

Summary: Humoral immune responses are dysregulated with aging, but the cellular and molecular pathways involved remain incompletely understood. In particular, little is known about the effects of aging on T follicular helper (Tfh) CD4 cells, the key cells that provide help to B cells for effective h...

Full description

Bibliographic Details
Main Authors: Ramin Sedaghat Herati, Luisa Victoria Silva, Laura A. Vella, Alexander Muselman, Cecile Alanio, Bertram Bengsch, Raj K. Kurupati, Senthil Kannan, Sasikanth Manne, Andrew V. Kossenkov, David H. Canaday, Susan A. Doyle, Hildegund C.J. Ertl, Kenneth E. Schmader, E. John Wherry
Format: Article
Language:English
Published: Elsevier 2021-05-01
Series:Cell Reports Medicine
Subjects:
T follicular helper
vaccine
NF-kB
aging
cellular biosensors
CD4
Online Access:http://www.sciencedirect.com/science/article/pii/S2666379121000781

Internet

http://www.sciencedirect.com/science/article/pii/S2666379121000781

Similar Items