Vaccine-induced ICOS+CD38+ circulating Tfh are sensitive biosensors of age-related changes in inflammatory pathways
Summary: Humoral immune responses are dysregulated with aging, but the cellular and molecular pathways involved remain incompletely understood. In particular, little is known about the effects of aging on T follicular helper (Tfh) CD4 cells, the key cells that provide help to B cells for effective h...
Main Authors: | Ramin Sedaghat Herati, Luisa Victoria Silva, Laura A. Vella, Alexander Muselman, Cecile Alanio, Bertram Bengsch, Raj K. Kurupati, Senthil Kannan, Sasikanth Manne, Andrew V. Kossenkov, David H. Canaday, Susan A. Doyle, Hildegund C.J. Ertl, Kenneth E. Schmader, E. John Wherry |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2021-05-01
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Series: | Cell Reports Medicine |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2666379121000781 |
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