Infectious Agents in the Pathogenesis of Primary Biliary Cirrhosis

Primary biliary cirrhosis (PBC) is a chronic progressive cholestatic liver disease which is characterized by the breakdown of self-tolerance to the highly conserved pyruvate dehydrogenase complex, specially the pyruvate dehydrogenase E2 complex (PDC-E2). The breakdown of the tolerance to such antige...

Full description

Bibliographic Details
Main Authors: Oscar-Danilo Ortega-Hernandez, Nancy-Agmon Levin, Arie Altman, Yehuda Shoenfeld
Format: Article
Language:English
Published: Hindawi Limited 2010-01-01
Series:Disease Markers
Online Access:http://dx.doi.org/10.3233/DMA-2010-0771