Risk-associated alterations in marrow T cells in pediatric leukemia

Risk-associated alterations in marrow T cells in pediatric leukemia

Current management of childhood leukemia is tailored based on disease risk determined by clinical features at presentation. Whether properties of the host immune response impact disease risk and outcome is not known. Here, we combine mass cytometry, single cell genomics, and functional studies to ch...

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Bibliographic Details
Main Authors: Jithendra Kini Bailur, Samuel S. McCachren, Katherine Pendleton, Juan C. Vasquez, Hong Seo Lim, Alyssa Duffy, Deon B. Doxie, Akhilesh Kaushal, Connor Foster, Deborah DeRyckere, Sharon Castellino, Melissa L. Kemp, Peng Qiu, Madhav V. Dhodapkar, Kavita M. Dhodapkar
Format: Article
Language:English
Published: American Society for Clinical investigation 2020-08-01
Series:JCI Insight
Subjects:
Immunology
Online Access:https://doi.org/10.1172/jci.insight.140179

Internet

https://doi.org/10.1172/jci.insight.140179

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