Neuronal hyperexcitability is a DLK-dependent trigger of herpes simplex virus reactivation that can be induced by IL-1

Neuronal hyperexcitability is a DLK-dependent trigger of herpes simplex virus reactivation that can be induced by IL-1

Herpes simplex virus-1 (HSV-1) establishes a latent infection in neurons and periodically reactivates to cause disease. The stimuli that trigger HSV-1 reactivation have not been fully elucidated. We demonstrate HSV-1 reactivation from latently infected mouse neurons induced by forskolin requires neu...

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Bibliographic Details
Main Authors: Sean R Cuddy, Austin R Schinlever, Sara Dochnal, Philip V Seegren, Jon Suzich, Parijat Kundu, Taylor K Downs, Mina Farah, Bimal N Desai, Chris Boutell, Anna R Cliffe
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-12-01
Series:eLife
Subjects:
herpes simplex virus
IL-1
epigenetics
dual leucine zipper kinase
hyperexcitability
Online Access:https://elifesciences.org/articles/58037

Internet

https://elifesciences.org/articles/58037

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