Modulation of Rab7a-mediated growth factor receptor trafficking inhibits islet beta cell apoptosis and autophagy under conditions of metabolic stress

Modulation of Rab7a-mediated growth factor receptor trafficking inhibits islet beta cell apoptosis and autophagy under conditions of metabolic stress

Abstract Regenerative medicine approaches to enhancing beta cell growth and survival represent potential treatments for diabetes. It is known that growth factors such as insulin, IGF-1 and HGF support beta cell growth and survival, but in people with type 2 diabetes the destructive effects of metabo...

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Bibliographic Details
Main Authors: Nirun V. Hewawasam, Fadel Lhaf, Henry A. Taylor, Katrina Viloria, Amazon Austin, Aileen King, Peter Jones, Lucy Jones, Mark D. Turner, Natasha J. Hill
Format: Article
Language:English
Published: Nature Publishing Group 2020-09-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-020-72939-y

Internet

https://doi.org/10.1038/s41598-020-72939-y

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