Age-dependent alpha-synuclein accumulation and aggregation in the colon of a transgenic mouse model of Parkinson’s disease

Age-dependent alpha-synuclein accumulation and aggregation in the colon of a transgenic mouse model of Parkinson’s disease

Abstract Background Parkinson’s disease (PD) is one of the most common neurodegenerative diseases, neuropathologically characterized by misfolded protein aggregation, called Lewy bodies and Lewy neurites. PD is a slow-progressive disease with colonic dysfunction appearing in the prodromal stage and...

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Bibliographic Details
Main Authors: Qian-Qian Chen, Caroline Haikal, Wen Li, Ming-Tao Li, Zhan-You Wang, Jia-Yi Li
Format: Article
Language:English
Published: BMC 2018-06-01
Series:Translational Neurodegeneration
Subjects:
Parkinson’s disease
Colon
α-syn
Phosphorylation
VIP
nNOS
Online Access:http://link.springer.com/article/10.1186/s40035-018-0118-8

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http://link.springer.com/article/10.1186/s40035-018-0118-8

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