The A2B Adenosine Receptor Modulates the Epithelial– Mesenchymal Transition through the Balance of cAMP/PKA and MAPK/ERK Pathway Activation in Human Epithelial Lung Cells

The A2B Adenosine Receptor Modulates the Epithelial– Mesenchymal Transition through the Balance of cAMP/PKA and MAPK/ERK Pathway Activation in Human Epithelial Lung Cells

The epithelial-mesenchymal transition (EMT) is a complex process in which cell phenotype switches from the epithelial to mesenchymal one. The deregulations of this process have been related with the occurrence of different diseases such as lung cancer and fibrosis. In the last decade, several effort...

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Bibliographic Details
Main Authors: Chiara Giacomelli, Simona Daniele, Chiara Romei, Laura Tavanti, Tommaso Neri, Ilaria Piano, Alessandro Celi, Claudia Martini, Maria L. Trincavelli
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Pharmacology
Subjects:
adenosine A2B receptor
epithelial mesenchymal transition
lung
MAPK-ERK
cAMP-PKA
transforming growth factor-β1
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2018.00054/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2018.00054/full

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