T Cell Dysregulation in Non-silicotic Silica Exposed Workers: A Step Toward Immune Tolerance Breakdown

T Cell Dysregulation in Non-silicotic Silica Exposed Workers: A Step Toward Immune Tolerance Breakdown

Background: Chronic silica exposure can lead to silicosis, complicated or not by autoimmune diseases (AID). The pathophysiology of silica-induced AID remains not fully understood, especially immune mechanisms that may develop in patients without yet established silicosis. We conducted a prospective...

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Bibliographic Details
Main Authors: Benoit Brilland, Céline Beauvillain, Gery Mazurkiewicz, Pierre Rucay, Yves Roquelaure, Julie Tabiasco, Emeline Vinatier, Jérémie Riou, Pascale Jeannin, Gilles Renier, Jean-François Subra, Jean-François Augusto
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Immunology
Subjects:
crystalline silica
occupational diseases
auto-immune diseases
activated T cells
regulatory T cells
auto-antibodies
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02743/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.02743/full

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