Seco-B-Ring Steroidal Dienynes with Aromatic D Ring: Design, Synthesis and Biological Evaluation

Seco-B-Ring Steroidal Dienynes with Aromatic D Ring: Design, Synthesis and Biological Evaluation

Continuing our structure-activity studies on the vitamin D analogs with the altered intercyclic seco-B-ring fragment, we designed compounds possessing dienyne system conjugated with the benzene D ring. Analysis of the literature data and the docking experiments seemed to indicate that the target com...

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Bibliographic Details
Main Authors: Marcin Szybinski, Pawel Brzeminski, Adrian Fabisiak, Klaudia Berkowska, Ewa Marcinkowska, Rafal R. Sicinski
Format: Article
Language:English
Published: MDPI AG 2017-10-01
Series:International Journal of Molecular Sciences
Subjects:
steroidal dienynes
B-seco steroids
Sonogashira reaction
vitamin D receptor
HL-60 cell differentiation
Online Access:https://www.mdpi.com/1422-0067/18/10/2162

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https://www.mdpi.com/1422-0067/18/10/2162

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