Microbiota-Derived Metabolites, Indole-3-aldehyde and Indole-3-acetic Acid, Differentially Modulate Innate Cytokines and Stromal Remodeling Processes Associated with Autoimmune Arthritis

Microbiota-Derived Metabolites, Indole-3-aldehyde and Indole-3-acetic Acid, Differentially Modulate Innate Cytokines and Stromal Remodeling Processes Associated with Autoimmune Arthritis

Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation of the synovial joints. Inflammation, new blood vessel formation (angiogenesis) and bone resorption (osteoclastogenesis) are three key processes involved in the joint damage and deformities of arthritis. Various...

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Bibliographic Details
Main Authors: David Langan, Darren J. Perkins, Stefanie N. Vogel, Kamal D. Moudgil
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:International Journal of Molecular Sciences
Subjects:
rheumatoid arthritis
microbiota
indole-3-acetic acid
indole-3-aldehyde
aryl hydrocarbon receptor
NF-κB
Online Access:https://www.mdpi.com/1422-0067/22/4/2017

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https://www.mdpi.com/1422-0067/22/4/2017

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