Osteocyte-Intrinsic TGF-β Signaling Regulates Bone Quality through Perilacunar/Canalicular Remodeling

Osteocyte-Intrinsic TGF-β Signaling Regulates Bone Quality through Perilacunar/Canalicular Remodeling

Poor bone quality contributes to bone fragility in diabetes, aging, and osteogenesis imperfecta. However, the mechanisms controlling bone quality are not well understood, contributing to the current lack of strategies to diagnose or treat bone quality deficits. Transforming growth factor beta (TGF-β...

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Bibliographic Details
Main Authors: Neha S. Dole, Courtney M. Mazur, Claire Acevedo, Justin P. Lopez, David A. Monteiro, Tristan W. Fowler, Bernd Gludovatz, Flynn Walsh, Jenna N. Regan, Sara Messina, Daniel S. Evans, Thomas F. Lang, Bin Zhang, Robert O. Ritchie, Khalid S. Mohammad, Tamara Alliston
Format: Article
Language:English
Published: Elsevier 2017-11-01
Series:Cell Reports
Subjects:
osteocyte
TGF-β
bone quality
perilacunar/canalicular remodeling
bone fragility
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717315954

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http://www.sciencedirect.com/science/article/pii/S2211124717315954

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