Cholesterol and CDON Regulate Sonic Hedgehog Release from Pancreatic Cancer Cells
Background: Sonic Hedgehog (Shh) is a tightly regulated membrane-associated morphogen and a known driver of tumorigenesis in pancreatic ductal adenocarcinoma (PDAC). After processing, Shh remains at the plasma membrane of Shh producing cells, thereby limiting its distribution and signal strength. In...
| Format: | Article |
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| Language: | English |
| Published: |
Mary Ann Liebert
2021-06-01
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| Series: | Journal of Pancreatic Cancer |
| Online Access: | https://www.liebertpub.com/doi/full/10.1089/PANCAN.2021.0002 |