Phorbol 12-Myristate 13-Acetate Induced Toxicity Study and the Role of Tangeretin in Abrogating HIF-1α-NF-κB Crosstalk In Vitro and In Vivo

Phorbol 12-Myristate 13-Acetate Induced Toxicity Study and the Role of Tangeretin in Abrogating HIF-1α-NF-κB Crosstalk In Vitro and In Vivo

Phorbol 12-myristate 13-acetate (PMA) is a potent tumor promoter and highly inflammatory in nature. Here, we investigated the toxic effects of PMA on different model system. PMA (10 μg) caused chromosomal aberrations on the <i>Allium cepa</i> root tip and induced mitotic dysfunction. Sim...

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Bibliographic Details
Main Authors: Sukkum Ngullie Chang, Debasish Kumar Dey, Seong Taek Oh, Won Ho Kong, Kiu Hyung Cho, Ebtesam M. Al-Olayan, Buyng Su Hwang, Sun Chul Kang, Jae Gyu Park
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:International Journal of Molecular Sciences
Subjects:
phorbol 12-myristate 13-acetate (PMA)
<i>allium cepa</i> test
zebrafish embryotoxicity test
inflammation
tangeretin (TAN)
nuclear factor kappa-light-chain-enhancer of activated b cells (NF-κb)
Online Access:https://www.mdpi.com/1422-0067/21/23/9261

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https://www.mdpi.com/1422-0067/21/23/9261

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