The D355V Mutation Decreases EGR2 Binding to an Element within the Cx32 Promoter

The D355V Mutation Decreases EGR2 Binding to an Element within the Cx32 Promoter

Mutations in the early growth response 2 (EGR2) gene are associated with some forms of Charcot–Marie–Tooth disease (CMT) and other demyelinating neuropathies. These mutations modify the EGR2 binding to specific DNA sequences suggesting a role in the transcriptional control of myelination-specific ge...

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Bibliographic Details
Main Authors: Marco Musso, Piercesare Balestra, Emilia Bellone, Denise Cassandrini, Emilio Di Maria, Laura Lamba Doria, Marina Grandis, GianLuigi Mancardi, Angelo Schenone, Giovanni Levi, Franco Ajmar, Paola Mandich
Format: Article
Language:English
Published: Elsevier 2001-08-01
Series:Neurobiology of Disease
Subjects:
EGR2
Krox20
Cx32
Charcot–Marie–Tooth disease
myelination
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996101903973

Internet

http://www.sciencedirect.com/science/article/pii/S0969996101903973

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