Topical Ascorbic Acid Ameliorates Oxidative Stress-Induced Corneal Endothelial Damage via Suppression of Apoptosis and Autophagic Flux Blockage

Topical Ascorbic Acid Ameliorates Oxidative Stress-Induced Corneal Endothelial Damage via Suppression of Apoptosis and Autophagic Flux Blockage

Compromised pumping function of the corneal endothelium, due to loss of endothelial cells, results in corneal edema and subsequent visual problems. Clinically and experimentally, oxidative stress may cause corneal endothelial decompensation after phacoemulsification. Additionally, in vitro and anima...

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Bibliographic Details
Main Authors: Yi-Jen Hsueh, Yaa-Jyuhn James Meir, Lung-Kun Yeh, Tze-Kai Wang, Chieh-Cheng Huang, Tsai-Te Lu, Chao-Min Cheng, Wei-Chi Wu, Hung-Chi Chen
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Cells
Subjects:
ascorbic acid
oxidative stress
apoptosis
autophagic flux blockage
PI3K/Akt
corneal endothelial cells
Online Access:https://www.mdpi.com/2073-4409/9/4/943

Internet

https://www.mdpi.com/2073-4409/9/4/943

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