Metabolic activation and toxicological evaluation of polychlorinated biphenyls in Drosophila melanogaster

Metabolic activation and toxicological evaluation of polychlorinated biphenyls in Drosophila melanogaster

Abstract Degradation of polychlorinated biphenyls (PCBs) is initiated by cytochrome P450 (CYP) enzymes and includes PCB oxidation to OH-metabolites, which often display a higher toxicity than their parental compounds. In search of an animal model reflecting PCB metabolism and toxicity, we tested Dro...

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Bibliographic Details
Main Authors: T. Idda, C. Bonas, J. Hoffmann, J. Bertram, N. Quinete, T. Schettgen, K. Fietkau, A. Esser, M. B. Stope, M. M. Leijs, J. M. Baron, T. Kraus, A. Voigt, P. Ziegler
Format: Article
Language:English
Published: Nature Publishing Group 2020-12-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-020-78405-z

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https://doi.org/10.1038/s41598-020-78405-z

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