Loss of exosomal miR-146a-5p from cancer-associated fibroblasts after androgen deprivation therapy contributes to prostate cancer metastasis

Loss of exosomal miR-146a-5p from cancer-associated fibroblasts after androgen deprivation therapy contributes to prostate cancer metastasis

Abstract Background Androgen deprivation therapy (ADT) is the backbone of therapy for advanced prostate cancer (PCa). Despite the good initial response, castration resistance and metastatic progression will inevitably occur. Cancer-associated fibroblasts (CAFs) may be implicated in promoting metasta...

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Bibliographic Details
Main Authors: Yu Zhang, Jing Zhao, Mao Ding, Yiming Su, Di Cui, Chenyi Jiang, Sheng Zhao, Gaozhen Jia, Xiaohai Wang, Yuan Ruan, Yifeng Jing, Shujie Xia, Bangmin Han
Format: Article
Language:English
Published: BMC 2020-12-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Prostate cancer
Androgen deprivation therapy (ADT)
Metastasis
Cancer-associated fibroblasts (CAFs)
Exosomes
Online Access:https://doi.org/10.1186/s13046-020-01761-1

Internet

https://doi.org/10.1186/s13046-020-01761-1

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