DNA methylation changes separate allergic patients from healthy controls and may reflect altered CD4+ T-cell population structure.

DNA methylation changes separate allergic patients from healthy controls and may reflect altered CD4+ T-cell population structure.

Altered DNA methylation patterns in CD4(+) T-cells indicate the importance of epigenetic mechanisms in inflammatory diseases. However, the identification of these alterations is complicated by the heterogeneity of most inflammatory diseases. Seasonal allergic rhinitis (SAR) is an optimal disease mod...

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Bibliographic Details
Main Authors: Colm E Nestor, Fredrik Barrenäs, Hui Wang, Antonio Lentini, Huan Zhang, Sören Bruhn, Rebecka Jörnsten, Michael A Langston, Gary Rogers, Mika Gustafsson, Mikael Benson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC3879208?pdf=render

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http://europepmc.org/articles/PMC3879208?pdf=render

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