The neuronal calcium sensor Synaptotagmin-1 and SNARE proteins cooperate to dilate fusion pores

The neuronal calcium sensor Synaptotagmin-1 and SNARE proteins cooperate to dilate fusion pores

All membrane fusion reactions proceed through an initial fusion pore, including calcium-triggered release of neurotransmitters and hormones. Expansion of this small pore to release cargo is energetically costly and regulated by cells, but the mechanisms are poorly understood. Here, we show that the...

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Bibliographic Details
Main Authors: Zhenyong Wu, Nadiv Dharan, Zachary A McDargh, Sathish Thiyagarajan, Ben O'Shaughnessy, Erdem Karatekin
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-06-01
Series:eLife
Subjects:
exocytosis
SNARE proteins
Synaptotagmin-1
calcium-triggered neurotransmitter release
membrane fusion
fusion pore
Online Access:https://elifesciences.org/articles/68215

Internet

https://elifesciences.org/articles/68215

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