<i>DPYD</i> Exome, mRNA Expression and Uracil Levels in Early Severe Toxicity to Fluoropyrimidines: An Extreme Phenotype Approach

<i>DPYD</i> Exome, mRNA Expression and Uracil Levels in Early Severe Toxicity to Fluoropyrimidines: An Extreme Phenotype Approach

Dihydropyrimidine dehydrogenase deficiency is a major cause of severe fluoropyrimidine-induced toxicity and could lead to interruption of chemotherapy or life-threatening adverse reactions. This study aimed to characterize the <i>DPYD</i> exon sequence, mRNA expression and in vivo DPD ac...

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Bibliographic Details
Main Authors: Priscila Villalvazo, Belén Marzal-Alfaro, Pilar García-Alfonso, José Luis Revuelta-Herrero, Fabienne Thomas, Sara López-Tarruella, Xandra García-González, Aitana Calvo, Malika Yakoubi, Sara Salvador-Martín, Flora López-López, Iker Aguilar, María Sanjurjo-Sáez, Miguel Martín, Luis Andrés López-Fernández
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Journal of Personalized Medicine
Subjects:
pharmacogenetics
cancer
adverse drug events
capecitabine
5-fluorouracil
Online Access:https://www.mdpi.com/2075-4426/11/8/792

Internet

https://www.mdpi.com/2075-4426/11/8/792

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