ALKBH5 suppresses tumor progression via an m6A-dependent epigenetic silencing of pre-miR-181b-1/YAP signaling axis in osteosarcoma

ALKBH5 suppresses tumor progression via an m6A-dependent epigenetic silencing of pre-miR-181b-1/YAP signaling axis in osteosarcoma

Abstract ALKBH5 is the main enzyme for m6A-based demethylation of RNAs and it has been implicated in many biological and pathophysiological processes. Here, we aimed to explore the potential involvement of ALKBH5 in osteosarcoma and decipher the underlying cellular/molecular mechanisms. We discovere...

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Bibliographic Details
Main Authors: Ye Yuan, Gege Yan, Mingyu He, Hong Lei, Linqiang Li, Yang Wang, Xiaoqi He, Guanghui Li, Quan Wang, Yuelin Gao, Zhezhe Qu, Zhongting Mei, Zhihua Shen, Jiaying Pu, Ao Wang, Wei Zhao, Huiwei Jiang, Weijie Du, Lei Yang
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-020-03315-x

Internet

https://doi.org/10.1038/s41419-020-03315-x

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