Isolation and Assessment of the in Vitro Anti-Tumor Activity of Smenothiazole A and B, Chlorinated Thiazole-Containing Peptide/Polyketides from the Caribbean Sponge, Smenospongia aurea

Isolation and Assessment of the in Vitro Anti-Tumor Activity of Smenothiazole A and B, Chlorinated Thiazole-Containing Peptide/Polyketides from the Caribbean Sponge, Smenospongia aurea

The study of the secondary metabolites contained in the organic extract of Caribbean sponge Smenospongia aurea led to the isolation of smenothiazole A (3) and B (4), hybrid peptide/polyketide compounds. Assays performed using four solid tumor cell lines showed that smenothiazoles exert a potent cyt...

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Bibliographic Details
Main Authors: Germana Esposito, Roberta Teta, Roberta Miceli, Luca S. Ceccarelli, Gerardo Della Sala, Rosa Camerlingo, Elena Irollo, Alfonso Mangoni, Giuseppe Pirozzi, Valeria Costantino
Format: Article
Language:English
Published: MDPI AG 2015-01-01
Series:Marine Drugs
Subjects:
Smenospongia aurea
marine natural products
thiazole
structure elucidation
anti-tumor lead molecules
smenamides
solid tumor cell lines
apoptosis
MTT assays
Online Access:http://www.mdpi.com/1660-3397/13/1/444

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http://www.mdpi.com/1660-3397/13/1/444

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