CO2 directly modulates connexin 26 by formation of carbamate bridges between subunits

CO2 directly modulates connexin 26 by formation of carbamate bridges between subunits

Homeostatic regulation of the partial pressure of CO2 (PCO2) is vital for life. Sensing of pH has been proposed as a sufficient proxy for determination of PCO2 and direct CO2-sensing largely discounted. Here we show that connexin 26 (Cx26) hemichannels, causally linked to respiratory chemosensitivit...

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Bibliographic Details
Main Authors: Louise Meigh, Sophie A Greenhalgh, Thomas L Rodgers, Martin J Cann, David I Roper, Nicholas Dale
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2013-11-01
Series:eLife
Subjects:
respiratory chemosensitivity
connexin
signal transduction
membrane channel
Online Access:https://elifesciences.org/articles/01213

Internet

https://elifesciences.org/articles/01213

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