Rapid transport of insulin to the brain following intranasal administration in rats

Rapid transport of insulin to the brain following intranasal administration in rats

We previously reported that intranasal insulin protects substantia nigra dopaminergic neurons against 6-hydroxydopamine neurotoxicity in rats. This study aimed to assess insulin pharmacokinetics in the rat brain following intranasal application. Recombinant human insulin (rh-Ins) or phosphate buffer...

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Bibliographic Details
Main Authors: Lir-Wan Fan, Kathleen Carter, Abhay Bhatt, Yi Pang
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2019-01-01
Series:Neural Regeneration Research
Subjects:
dopaminergic neurons; striatum; substantia nigra; brainstem; olfactory bulb; glia; trigeminal nerve; pharmacokinetics; axonal transport; pAkt
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2019;volume=14;issue=6;spage=1046;epage=1051;aulast=Fan

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http://www.nrronline.org/article.asp?issn=1673-5374;year=2019;volume=14;issue=6;spage=1046;epage=1051;aulast=Fan

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