How Does the CO<sub>2</sub> in Supercritical State Affect the Properties of Drug-Polymer Systems, Dissolution Performance and Characteristics of Tablets Containing Bicalutamide?

How Does the CO<sub>2</sub> in Supercritical State Affect the Properties of Drug-Polymer Systems, Dissolution Performance and Characteristics of Tablets Containing Bicalutamide?

The increasing demand for novel drug formulations has caused the introduction of the supercritical fluid technology, CO<sub>2</sub> in particular, into pharmaceutical technology as a method enabling the reduction of particle size and the formation of inclusion complexes and solid dispers...

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Bibliographic Details
Main Authors: Agata Antosik-Rogóż, Joanna Szafraniec‑Szczęsny, Krzysztof Chmiel, Justyna Knapik-Kowalczuk, Mateusz Kurek, Karolina Gawlak, Vittorio P. Danesi, Marian Paluch, Renata Jachowicz
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Materials
Subjects:
Bicalutamide
Poloxamer<sup>®</sup> 407
Macrogol 6000
supercritical carbon dioxide
solid dispersions
dissolution rate
Online Access:https://www.mdpi.com/1996-1944/13/12/2848

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https://www.mdpi.com/1996-1944/13/12/2848

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