OX1 and OX2 orexin/hypocretin receptor pharmacogenetics

OX1 and OX2 orexin/hypocretin receptor pharmacogenetics

Orexin/hypocretin peptide mutations are rare in humans. Even though human narcolepsy is associated with orexin deficiency, this is only extremely rarely due to mutations in the gene coding prepro-orexin, the precursor for both orexin peptides. In contrast, coding and non-coding variants of the OX1 a...

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Bibliographic Details
Main Authors: Miles Douglas Thompson, Henri eXhaard, Takeshi eSakurai, Innocenzo eRainero, Jyrki P. Kukkonen
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-05-01
Series:Frontiers in Neuroscience
Subjects:
Pharmacogenetics
hypocretin
orexin
polymorphism
G protein-coupled receptor
prepro-orexin
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnins.2014.00057/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnins.2014.00057/full

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