Sphingolipid Synthesis Inhibition by Myriocin Administration Enhances Lipid Consumption and Ameliorates Lipid Response to Myocardial Ischemia Reperfusion Injury

Sphingolipid Synthesis Inhibition by Myriocin Administration Enhances Lipid Consumption and Ameliorates Lipid Response to Myocardial Ischemia Reperfusion Injury

Myocardial infarct requires prompt thrombolytic therapy or primary percutaneous coronary intervention to limit the extent of necrosis, but reperfusion creates additional damage. Along with reperfusion, a maladaptive remodeling phase might occur and it is often associated with inflammation, oxidative...

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Bibliographic Details
Main Authors: Fabiola Bonezzi, Marco Piccoli, Michele Dei Cas, Rita Paroni, Alessandra Mingione, Michelle M. Monasky, Anna Caretti, Chiara Riganti, Riccardo Ghidoni, Carlo Pappone, Luigi Anastasia, Paola Signorelli
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Physiology
Subjects:
sphingolipids
ceramide
myriocin
ischemia
reperfusion
metabolism
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.00986/full

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https://www.frontiersin.org/article/10.3389/fphys.2019.00986/full

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