Maackiain, a compound derived from Sophora flavescens, increases IL‐1β production by amplifying nigericin‐mediated inflammasome activation

Maackiain, a compound derived from Sophora flavescens, increases IL‐1β production by amplifying nigericin‐mediated inflammasome activation

Sophora flavescens is used as a traditional herbal medicine to modulate inflammatory responses. However, little is known about the impact of (‐)‐maackiain, a compound derived from S. flavescens, on the activation of inflammasome/caspase‐1, a key factor in interleukin‐1β (IL‐1β) processing. Here, we...

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Bibliographic Details
Main Authors: Jin‐Won Huh, Jung‐Hoon Lee, Eekhyoung Jeon, Hyung Won Ryu, Sei‐Ryang Oh, Kyung‐Seop Ahn, Hyun Sik Jun, Un‐Hwan Ha
Format: Article
Language:English
Published: Wiley 2020-08-01
Series:FEBS Open Bio
Subjects:
(‐)‐maackiain
inflammasome
monophosphoryl lipid A
nigericin
Sophora flavescens
Online Access:https://doi.org/10.1002/2211-5463.12899

Internet

https://doi.org/10.1002/2211-5463.12899

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