SAMHD1 Promotes DNA End Resection to Facilitate DNA Repair by Homologous Recombination

SAMHD1 Promotes DNA End Resection to Facilitate DNA Repair by Homologous Recombination

DNA double-strand break (DSB) repair by homologous recombination (HR) is initiated by CtIP/MRN-mediated DNA end resection to maintain genome integrity. SAMHD1 is a dNTP triphosphohydrolase, which restricts HIV-1 infection, and mutations are associated with Aicardi-Goutières syndrome and cancer. We s...

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Bibliographic Details
Main Authors: Waaqo Daddacha, Allyson E. Koyen, Amanda J. Bastien, PamelaSara E. Head, Vishal R. Dhere, Geraldine N. Nabeta, Erin C. Connolly, Erica Werner, Matthew Z. Madden, Michele B. Daly, Elizabeth V. Minten, Donna R. Whelan, Ashley J. Schlafstein, Hui Zhang, Roopesh Anand, Christine Doronio, Allison E. Withers, Caitlin Shepard, Ranjini K. Sundaram, Xingming Deng, William S. Dynan, Ya Wang, Ranjit S. Bindra, Petr Cejka, Eli Rothenberg, Paul W. Doetsch, Baek Kim, David S. Yu
Format: Article
Language:English
Published: Elsevier 2017-08-01
Series:Cell Reports
Subjects:
DNA repair
DNA damage response
DNA end resection
HIV
AGS
CLL
CtIP
dNTP
homologous recombination
autoimmune
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717310963

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http://www.sciencedirect.com/science/article/pii/S2211124717310963

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