Vinpocetine inhibits RANKL-induced osteoclastogenesis and attenuates ovariectomy-induced bone loss

Vinpocetine inhibits RANKL-induced osteoclastogenesis and attenuates ovariectomy-induced bone loss

Osteoporosis is a result of impaired bone formation and/or excessive bone resorption. Osteoclasts are the only cells in the body that have a bone resorption function. Inhibiting osteoclast activity and differentiation is a way to treat osteoporosis. The current pharmacological treatment for osteopor...

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Bibliographic Details
Main Authors: Meipeng Zhu, Hui Liu, Kai Sun, Jian Liu, Yan Mou, Dahu Qi, Chuankun Zhou, Maihaiti Abudunaibi, Bahebieergan Tasiken, Jianwen Li, Hao Cheng, Hui Huang
Format: Article
Language:English
Published: Elsevier 2020-03-01
Series:Biomedicine & Pharmacotherapy
Subjects:
vinpocetine(Vinp)
Osteoporosis
Osteoclastogenesis
MAPK, NF‐κB
Reactive oxygen species
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332219353910

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http://www.sciencedirect.com/science/article/pii/S0753332219353910

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