Human T Cells Expressing a CD19 CAR-T Receptor Provide Insights into Mechanisms of Human CD19-Positive β Cell Destruction

Human T Cells Expressing a CD19 CAR-T Receptor Provide Insights into Mechanisms of Human CD19-Positive β Cell Destruction

Summary: Autoimmune destruction of pancreatic β cells underlies type 1 diabetes (T1D). To understand T cell-mediated immune effects on human pancreatic β cells, we combine β cell-specific expression of a model antigen, CD19, and anti-CD19 chimeric antigen receptor T (CAR-T) cells. Coculturing CD19-e...

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Bibliographic Details
Main Authors: Haiting Ma, Jacob F. Jeppesen, Rudolf Jaenisch
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Cell Reports Medicine
Subjects:
human pluripotent stem cells
regenerative medicine
pancreatic beta cells
autoimmune diabetes
CAR-T cells
pyroptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2666379120301233

Internet

http://www.sciencedirect.com/science/article/pii/S2666379120301233

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