Tet inactivation disrupts YY1 binding and long-range chromatin interactions during embryonic heart development

Tet inactivation disrupts YY1 binding and long-range chromatin interactions during embryonic heart development

Tet-mediated DNA demethylation is intimately involved in reguatling embryonic development. Here the authors characterise DNA methylation and hydroxymethylation dynamics during early cardiac development in both human and mice and provide evidence that Tet-mediated DNA demethylation plays a role in re...

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Bibliographic Details
Main Authors: Shaohai Fang, Jia Li, Yang Xiao, Minjung Lee, Lei Guo, Wei Han, Tingting Li, Matthew C. Hill, Tingting Hong, William Mo, Rang Xu, Ping Zhang, Fen Wang, Jiang Chang, Yubin Zhou, Deqiang Sun, James F. Martin, Yun Huang
Format: Article
Language:English
Published: Nature Publishing Group 2019-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-12325-z

Internet

https://doi.org/10.1038/s41467-019-12325-z

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